Cinzia Volonté
Cinzia Volonté Cinzia Volonté
Research Director
Dirigente di Ricerca

Unità di Ricerca "Fisiopatologia dello Shock", Università Cattolica del Sacro Cuore
Largo Agostino Gemelli, 8
00168 Roma - Italy

Office n. .
Tel.: 06 501703084
Personal web page: http://www.cnr.it/people/cinzia.volonte
email

Research interests

Research activity in my laboratory is focused on studying the pathophysiological functions of purinergic (ionotropic P2X, metabotropic P2Y) and histaminergic (H1-H4) receptors in the central nervous system. Main goals of current reaserch are: to understand the early and late events partaking to the neuronal and glial commitment to neurodegeneration and neuroinflammation; to identify the molecular interactors and signalling pathways that regulate the purinergic and histaminergic involvement in ALS and MS.

Our mission is finding innovative solutions and paradigms for therapy in ALS and MS pathogenesis.

 


Personal news

https://youtu.be/nALYPH0G4Sk


Research groups

Selected publications
  • Brandi R, Fabiano M, Giorgi C, Arisi I, La Regina F, Malerba F, Turturro S, Storti A, Ricevuti F, Amadio S, Cinzia Volonté, Capsoni S, Scardigli R, D'Onofrio M, Cattaneo A: Nerve Growth Factor neutralization promotes oligodendrogenesis by increasing miR-219a-5p levels., Cells 10(2):405, 2021
  • Klionsky DJ, et al et al, Cinzia Volonté, et al et al: Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th edition), Autophagy 17(1), 1-382, 2021
  • Martire A, Pepponi R, Liguori F, Cinzia Volonté, Popoli P: P2X7 receptor agonist 2’-3’-O-(4-Benzoylbenzoyl)-ATP differently modulates corticostriatal synaptic transmission and cell viability in experimental models of Huntington’s disease., Frontiers in Pharmacology 11:2488, 2021
  • Mascolo E, Liguori F, Stufera Mecarelli L, Amoroso N, Merigliano C, Amadio S, Cinzia Volonté, Contestabile R, Tramonti A, Vernì F: Functional inactivation of Drosophila GCK orthologs causes genomic instability and oxidative stress in a fly model of MODY-2, International Journal of Molecular Sciences, 22(2):918, doi: 10.3390/ijms22020918., 2021
  • Proietti D, Giordani L, De Bardi M, D'Ercole C, Lozanoska-Ochser B, Amadio S, Cinzia Volonté, Marinelli S, Muchir A, Bouchè M, Borsellino G, Sacco V, Puri PL, Madaro L: Activation of skeletal muscle-resident glial cells upon nerve injury., Journal of Clinical Investigations Insights 143469, 2021
  • Cinzia Volonté: What strikes most when we think of Geoff, Purinergic Signalling 17(1), 2021
  • Bernardino L, Cinzia Volonté, Passani AM, Ferreira R: Dual role of Microglia in Health and Disease: Pushing the Balance Toward Repair, Frontiers in Cellular Neuroscience, 14:259, doi: 10.3389/fncel.2020.00259. eCollection 2020, 2020
  • Coccurello R, Cinzia Volonté: P2X7 RECEPTOR IN THE MANAGEMENT OF ENERGY HOMEOSTASIS: IMPLICATIONS FOR OBESITY, DYSLIPIDEMIA AND INSULIN RESISTANCE, Frontiers in Endocrinology, 11:199, doi: 10.3389/fendo.2020.00199, 2020
  • Di Sante G, Amadio S, Sampaolese B, Clementi ME, Valentini MG, Cinzia Volonté, Casalbore P, Ria F, Michetti F: The S100B Inhibitor Pentamidine Ameliorates Clinical Score and Neuropathology of Relapsing— Remitting Multiple Sclerosis Mouse Model, Cells, 9(3):748. Cellular and Molecular Mechanisms in Pathogenesis of Multiple Sclerosis, https://www.mdpi.com/2073-4409/9/3/748, 2020
  • Fabbrizio P, Apolloni S, Bianchi A, Salvatori I, Valle C, Lanzuolo C, Bendotti C, Nardo G, Cinzia Volonté: P2X7 activation enhances skeletal muscle metabolism and regeneration in SOD1G93A mouse model of amyotrophic lateral sclerosis, Brain Pathology, 30(2):272-282, doi:10.1111/bpa.12774, 2020
  • Cinzia Volonté, Amadio S, Liguori F: Duality of P2X7 Receptor in Amyotrophic Lateral Sclerosis, Frontiers in Pharmacology, 11:1148, doi: 10.3389/fphar.2020.01148, 2020
  • Cinzia Volonté, Morello G, Spampinato AG, Amadio S, Apolloni S, D'Agata V, Cavallaro S: Omics-based exploration and functional validation of neurotrophic factors and histamine as therapeutic targets in AL, Ageing Research Review, 62:101121, doi: 10.1016/j.arr.2020.101121, 2020
  • Apolloni S, Caputi F, Pignataro A, Amadio S, Fabbrizio P, Ammassari-Teule M, Cinzia Volonté: Histamine Is an Inducer of the Heat Shock Response in SOD1-G93A Models of ALS., International Journal of Molecular Sciences, 20(15):3793, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696457/, 2019
  • Giacovazzo G, Fabbrizio P, Apolloni S, Coccurello R, Cinzia Volonté: Stimulation of P2X7 Enhances Whole Body Energy Metabolism in Mice, Frontiers in Cellular Neuroscience, 13:390, ://www.frontiersin.org/articles/10.3389/fncel.2019.00390/full, 2019
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