Carmela Sinisgalli
Carmela Sinisgalli Carmela Sinisgalli
Researcher

Istituto di Analisi dei Sistemi ed Informatica "Antonio Ruberti"
Via dei Taurini, 19
00185 Roma - Italy

Office n. 515
Tel.: +39 06 4993 7131
Fax: +39 06 4993 7137
email

Research groups

Selected publications
  • Bruni C., Federica Conte, Federico Papa, Carmela Sinisgalli: Optimal number and sizes of the doses in fractionated radiotherapy according to the LQ model, Mathematical Medicine and Biology 36, 1-53, 2019
  • Federico Papa, Giovanni Felici, Franzetti M, Gandolfi A., Carmela Sinisgalli: Impact of ART-induced viral suppression on the HIV epidemic in Italy, Mathematical Medicine and Biology, 2019
  • Federico Papa, Binda F, Giovanni Felici, Franzetti M, Gandolfi A., Carmela Sinisgalli, Balotta C: A simple model of HIV epidemic in Italy: the role of the anti-retroviral treatment, Mathematical Biosciences and Engineering 15, 181-207, 2018
  • Federico Papa, Balotta C, Giovanni Felici, Franzetti M, Gandolfi A., Servilio M., Carmela Sinisgalli: Partial vs. complete response to antiretroviral treatments in a model of the HIV epidemic in Italy, presented at MOBI 2017, 2017
  • Alessandro Bertuzzi, Federica Conte, Mingrone G., Federico Papa, Salinari S., Carmela Sinisgalli: Insulin Signaling in Insulin Resistance States and Cancer: A Modeling Analysis, Plos One, http://dx.doi.org/10.1371/journal.pone.0154415, 2016
  • Bruni C., Federica Conte, Federico Papa, Carmela Sinisgalli: Optimal number and sizes of the doses in fractionated radiotherapy, IASI-CNR, R. 16-06, 9/2016
  • Federico Papa, Binda F, Giovanni Felici, Franzetti M, Gandolfi A., Carmela Sinisgalli, Balotta C: A simple model of HIV epidemic in Italy: the role of the anti-retroviral treatment, IASI-CNR, R. 16-05, 9/2016
  • Federico Papa, Binda F, Giovanni Felici, Franzetti M, Gandolfi A., Carmela Sinisgalli, Balotta C: A simple model of HIV epidemic in Italy: the role of the anti-retroviral treatment, presented at SIMAI 2016, 2016
  • Bruni C, Federica Conte, Federico Papa, Carmela Sinisgalli: Optimal weekly scheduling in fractionated radiotherapy: effect of an upper bound on the dose fraction size, Journal of Mathematical Biology, 2015
  • Federica Conte, Federico Papa, Carmela Sinisgalli: Minimum value of the maximal entry of n-dimensional vectors with constant sum of the entries and of the squared entries, IASI-CNR, R. 15-10, 2015
  • Gandolfi A., Pugliese A., Carmela Sinisgalli: Epidemic dynamics and host immune response: a nested approach, Journal of Mathematical Biology 70, 399-435, 2015
  • Federico Papa, Binda F, Giovanni Felici, Franzetti M, Gandolfi A., Carmela Sinisgalli, Balotta C: A simple model of HIV epidemic in Italy: the role of the anti-retroviral treatment, presented at Mathematical and Computational Epidemiology of Infectious diseases 2015, 2015
  • Bertuzzi A, Fasano A., Carmela Sinisgalli: Conservation laws in cancer modeling, in: Mathematical Oncology 2013, Mathematical Oncology 2013, Springer Heidelberg Dordrecht London New York, New York (Stati Uniti d'America), 2014
  • Alessandro Bertuzzi, Bruni C., Federico Papa, Carmela Sinisgalli: Optimal solution for a cancer radiotherapy problem, Journal of Mathematical Biology 66, 311-349, 2013
  • Alessandro Bertuzzi, Fasano A., Gandolfi A., Carmela Sinisgalli: Modeling the evolution of a tumoral multicellular spheroid as a two-fluid Bingham-like system, Mathematical Models & Methods in Applied Sciences 23, 2561-2602, 2013
  • Alessandro Bertuzzi, Bruni C., Federico Papa, Carmela Sinisgalli: Optimal solution for a cancer radiotherapy problem, IASI-CNR, R. 11-18, 2011
  • Alessandro Bertuzzi, Bruni C., Federico Papa, Carmela Sinisgalli: Optimal solution for a cancer radiotherapy problem, presented at CIMAB & GASVA SIMAI Young Researcher Workshop, 2011
  • Federico Papa, Carmela Sinisgalli: Optimal solution for a cancer radiotherapy problem with a maximal damage constraint on normal tissues, IASI-CNR, R. 11-20, 2011
  • Alessandro Bertuzzi, Bruni C., Fasano A., Gandolfi A., Federico Papa, Carmela Sinisgalli: Response of tumor spheroids to radiation: modeling and parameter estimation, Bulletin of Mathematical Biology 72, 1069-1091, 2010
  • Alessandro Bertuzzi, Fasano A., Gandolfi A., Carmela Sinisgalli: Necrotic core in EMT6/Ro tumour spheroids: Is it caused by an ATP deficit?, Journal of Theoretical Biology 262, 142-150, 2010
  • Alessandro Bertuzzi, Bruni C., Fasano A., Gandolfi A., Federico Papa, Carmela Sinisgalli: Response of tumour spheroids to radiation: modelling and parameter estimation, IASI-CNR, R. 09-16, 2009
  • Alessandro Bertuzzi, Bruni C., Fasano A., Gandolfi A., Federico Papa, Carmela Sinisgalli: A mathematical model for the radiation response of tumour spheroids, presented at SIMAI 9th Congress, 2008
  • Alessandro Bertuzzi, Fasano A., Gandolfi A., Carmela Sinisgalli: Reoxygenation and split-dose response to radiation in a tumour model with Krogh-type vascular geometry, Bulletin of Mathematical Biology 70, 992-1012, 2008
  • Alessandro Bertuzzi, Fasano A., Gandolfi A., Carmela Sinisgalli: Tumour cords and their response to anticancer agents, in: Selected Topics in Cancer Modeling, Chaplain M., Bellomo N., De Angelis E. eds., Modeling and Simulation in Science, Engineering and Technology, Birkhauser Boston, 183-206, 2008
  • Arino O., Alessandro Bertuzzi, Gandolfi A., Sanchez E., Carmela Sinisgalli: A model with `growth retardation' for the kinetic heterogeneity of tumour cell populations, Mathematical Biosciences 206, 185-199, 2007
  • Alessandro Bertuzzi, Fasano A., Gandolfi A., Carmela Sinisgalli: A mathematical model of ATP production in a multicellular spheroid model with necrotic core, in the Proceedings of SysBioHealth Symposium 2007, Alberghina L., Milanesi L. eds., 2007
  • Alessandro Bertuzzi, Fasano A., Gandolfi A., Carmela Sinisgalli: ATP production and necrosis formation in a tumour spheroid model, Mathematical Modelling of Natural Phenomena 2, 30-46, 2007
  • Alessandro Bertuzzi, Fasano A., Gandolfi A., Carmela Sinisgalli: Cell resensitization after delivery of a cycle-specific anticancer drug and effect of dose splitting. Learning from tumour cords, Journal of Theoretical Biology 244, 388-399, 2007
  • Alessandro Bertuzzi, Fasano A., Gandolfi A., Carmela Sinisgalli: Reoxygenation and split-dose response to radiation in a tumour cord model, in the Proceedings of 23rd IFIP TC7, Conference on System Modelling and Optimization, Szymkat M., Korytowski A., Mitkowski W. eds., 2007
  • Alessandro Bertuzzi, Fasano A., Gandolfi A., Carmela Sinisgalli: The transport of specific monoclonal antibodies in tumour cords, in: Math Everywhere: Deterministic and Stochastic Modelling in Biomedicine, Economics and Industry, Morale D., Aletti G., Burger M., Micheletti A. eds., 151-164, 2007
  • Alessandro Bertuzzi, Fasano A., Gandolfi A., Carmela Sinisgalli: Cell Resensitization after Delivery of a Cycle-Specific Anticancer Drug and Effect of Dose Splitting: Learning from Tumour Cords, Journal of Theoretical Biology, 2006
  • Arino O., Alessandro Bertuzzi, Gandolfi A., Sanchez E., Carmela Sinisgalli: The asynchronous exponential growth property in a model for the kinetic heterogeneity of tumour cell populations, Journal of Mathematical Analysis and Applications 302, 521-542, 2005
  • Alessandro Bertuzzi, Fasano A., Filidoro L., Gandolfi A., Carmela Sinisgalli: Dynamics of tumour cords following changes in oxygen availability: A model including a delayed exit from quiescence, Mathematical and Computer Modelling 41, 1119-1135, 2005
  • Alessandro Bertuzzi, Fasano A., Gandolfi A., Carmela Sinisgalli: Interstitial pressure and extracellular fluid motion in tumour cords, Mathematical Biosciences and Engineering 2, 445-460, 2005
  • Alessandro Bertuzzi, Faretta M., Gandolfi A., Carmela Sinisgalli, Starace G., Valoti G., Ubezio P.: Kinetic heterogeneity of an experimental tumour revealed by BrdUrd incorporation and mathematical modelling, Bulletin of Mathematical Biology 64, 355-384, 2002
  • Alessandro Bertuzzi, Gandolfi A., Carmela Sinisgalli: Preference Regions of Ridge Regression and Ols According to Pitman's Criterion, Sankhya-The Indian Journal of Statistics Series B, 437-447, 1998
  • Alessandro Bertuzzi, Gandolfi A., Carmela Sinisgalli, Starace G.: Stima di parametri cinetici di popolazioni cellulari mediante citometria a flusso, in: Manuale GIC - Citometria a Flusso, Starace G. ed., Gruppo Italiano di Citometria, 177-189, 1998
  • Alessandro Bertuzzi, Gandolfi A., Carmela Sinisgalli, Iacoviello D.: Steel's potential doubling time and its estimation in cell populations affected by nonuniform cell loss, Mathematical Biosciences 143, 61-89, 1997
  • Alessandro Bertuzzi, Gandolfi A., Carmela Sinisgalli, Starace G., Ubezio P.: Cell loss and the concept of potential doubling time, Cytometry 29, 34-40, 1997
  • Alessandro Bertuzzi, Del Grosso N., Gandolfi A., Carmela Sinisgalli, Starace G.: Cell Cycle Analysis by the Relative Movement Approach: Effect of Variability across S-Phase of DNA Synthesis Rate, Cell Proliferation 28, 107-120, 1995
  • Alessandro Bertuzzi, Gandolfi A., Carmela Sinisgalli, Starace G.: Relationship between DNA Synthesis Rate and DNA-BrdUrd Distribution in Pulse Labelling Experiments, in: Mathematical Population Dynamics: Analysis of heterogeneity, Arino O., Axelrod D., Kimmel M. eds., Wuerz Publishing Winnipeg, 71-86, 1995
  • Alessandro Bertuzzi, Gandolfi A., Carmela Sinisgalli, Starace G.: Mathematical Methods for Cell Cycle Analysis from Flow Cytometric DNA-BrdUrd Distributions, Applied Mathematics and Computer Science 4, 247-256, 1994
  • Alessandro Bertuzzi, Gandolfi A., Carmela Sinisgalli, Starace G.: Cell Cycle Analysis from DNA-BrdUrd Distributions, European Journal of Histochemistry 37/suppl.~4, 7-14, 1993
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