Andrea De Gaetano
Andrea De Gaetano Andrea De Gaetano
Research Director

Unità di Ricerca "Fisiopatologia dello Shock", Università Cattolica del Sacro Cuore
Largo Agostino Gemelli, 8
00185 Roma - Italy

Office n. 0
Tel.: +39 06 30155389
Fax: +39 06 3057845
Personal web page: www.biomatematica.it
email

Research interests

Parameter estimation for ordinary, delay and stochastic differential models

Modelling energy metabolism


Research groups

Selected publications
  • Borri A, Simona Panunzi, Pasquale Palumbo, Manes C., Andrea De Gaetano: Glucose control with incomplete information, IEEE Conference on Systems, Man and Cybernetics, 2016
  • Cibella F., Cutitta G., Della Maggiore R., Ruggieri S., Simona Panunzi, Andrea De Gaetano, Bucchieri S., Drago G., Melis MR, La Grutta S., Viegi G.: Effect of indoor nitrogen dioxide on lung function in urban environment, Environmental Research 138, 8-16, 2015
  • Simona Panunzi, Andrea De Gaetano, Carnicelli A., Mingrone G.: Predictors of Remission of Diabetes Mellitus in Severely Obese Individuals Undergoing Bariatric Surgery: Do BMI or Procedure Choice Matter? A Meta-analysis, Annals of Surgery 261, 459-467, 2015
  • Andrea De Gaetano, Simona Panunzi, Eliopoulos D., Hardy T., Mingrone G.: Mathematical Modeling of Renal Tubular Glucose Absorption after Glucose Load, Plos One 9, 2014
  • Andrea De Gaetano, Simona Panunzi, Pasquale Palumbo, Gaz C., Hardy T.: Data-driven modeling of diabetes progression, in: Data-driven models for Diabetes. Diagnosis and Treatment, Mitsis G, Marmarelis V eds., Lecture Notes in Bioengineering, Springer-Verlag Berlin Heidelberg, 165-186, 2014
  • Pasquale Palumbo, Pepe P., Simona Panunzi, Andrea De Gaetano: DDE model-based control of glycemia via sub-cutaneous insulin administration, in: Delay Systems. From Theory to Numerics and Applications, Sipahi R, Vyhlidal T, Lafay J-F eds., Advances in Delays and Dynamics, 1, Springer International Publishing, 229-240, 2014
  • Pasquale Palumbo, Pizzichelli G, Simona Panunzi, Pepe P., Andrea De Gaetano: Closed-loop control scheme for the euglycemic hyperinsulinemic clamp: validation on virtual patients, IFAC World Congress on Automatic Control, 2014
  • Pasquale Palumbo, Pizzichelli G, Simona Panunzi, Pepe P., Andrea De Gaetano: Model-based control of plasma glycemia: Tests on populations of virtual patients, Mathematical Biosciences 257, 2-10, 2014
  • Simona Panunzi, Alessandro Borri, Pasquale Palumbo, Kovacs L, Andrea De Gaetano: Simulation of insulin regimen and glucose profiles in Type 1 Diabetic Patient, IEEE Conference on Systems, Man and Cybernetics, 2014
  • Simona Panunzi, Andrea De Gaetano: Pitfalls in Model Identification: Examples from Glucose-Insulin Modelling, in: Data-driven Modeling for Diabetes, Mitsis G, Marmarelis V eds., Lecture Notes in Bioengineering, Springer-Verlag Berlin Heidelberg, 117-129, 2014
  • Gui D., Magalini S., Andrea De Gaetano, Simona Panunzi: Observational study on preoperative surgical field disinfection: Povidone-iodine and Chlorhexidine-alcohol, European review for medical and pharmacological sciences 17, 3367-3375, 2013
  • Pasquale Palumbo, Ditlevsen S., Alessandro Bertuzzi, Andrea De Gaetano: Mathematical modeling of the glucose-insulin system: a review, Mathematical Biosciences 244, 69-81, 2013
  • Pasquale Palumbo, Pepe P., Simona Panunzi, Andrea De Gaetano: Observer-based closed-loop control for the glucose-insulin system: local Input-to-State Stability with respect to unknown meal disturbances, American Control Conference (ACC13), 2013
  • Andrea De Gaetano, Matone A., Agnes A.M., Pasquale Palumbo, Ria F., Magalini S.: Modeling rejection immunity, Theoretical Biology and Medical Modelling 9, 2012
  • Li J., Wang M., Andrea De Gaetano, Pasquale Palumbo, Simona Panunzi: The range of time delay and the global stability of the equilibrium for an IVGTT model., Mathematical Biosciences 235, 128-137, 2012
  • Pasquale Palumbo, Pepe P., Simona Panunzi, Andrea De Gaetano: Observer-based glucose control via subcutaneous insulin administration, 8th IFAC Symposium on Biological and Medical Systems (BMS2012), 2012
  • Pasquale Palumbo, Pepe P., Simona Panunzi, Andrea De Gaetano: Time-delay model-based control of the glucose-insulin system, by means of a state observer, European Journal of Control, 2012
  • Pasquale Palumbo, Pepe P., Simona Panunzi, Andrea De Gaetano: Glucose control by subcutaneous insulin administration: a DDE modelling approach, in the Proceedings of 18th, IFAC World Congress on Automatic Control, 2011
  • Pasquale Palumbo, Pizzichelli G, Simona Panunzi, Pepe P., Andrea De Gaetano: Tests on a virtual patient for an observer-based, closed-loop control of plasma glycemia, 50th IEEE Conference on Decision and Control & 11th European Control Conference (CDC-ECC 2011), 2011
  • Pasquale Palumbo, Andrea De Gaetano: An islet population model of the endocrine pancreas, Journal of Mathematical Biology 61(2), 171-205, 2010
  • Simona Panunzi, Andrea De Gaetano, Mingrone G.: Advantages of the single delay model for the assessment of insulin sensitivity from the intravenous glucose tolerance test., Theoretical Biology and Medical Modelling, 2010
  • Morganti A., Cilla S., Valentini V., Digesù C., Macchia G., Deodato F., Ferrandina G., Cece M.G., Cirocco M., Garganese G., Di Lullo L., Traficante D., Scarabeo F., Simona Panunzi, Andrea De Gaetano, Sallustio G., Cellini N., Sofo L., Piermattei A., Scambia G.: Phase I-II Studies on Accelerated IMRT in Breast Carcinoma: Technical Comparison and Acute Toxicity in 332 Patients, Radiotherapy and Oncology 90, 86-92, 2009
  • Morganti A., Digesù C., Simona Panunzi, Andrea De Gaetano, Macchia G., Deodato F., Cece M.G., Cirocco M., Di Castelnuovo A., Iacoviello L., Valentini V., Cellini N., De Gaetano G.: Radioprotective Effect of Moderate Wine Consumption in Patients With Breast Carcinoma, International Journal of Radiation Oncology Biology Physics 74, 1501-1505, 2009
  • Pasquale Palumbo, Pepe P., Simona Panunzi, Andrea De Gaetano: Robust closed-loop control of plasma glycemia: a discrete-delay model approach, Discrete and Continuous Dynamical Systems-Series B Special Issue on Mathematical Biology and Medicine, 455-468, 2009
  • Picchini U., Andrea De Gaetano, Ditlevsen S.: Stochastic Differential Mixed-Effects Models, Scandinavian Journal of Statistics, 2009
  • Andrea De Gaetano, Hardy T., Beck B., Abu-Raddad E., Pasquale Palumbo, Blu-Valleskey J., Porksen N.: Mathematical models of diabetes progression, American Journal of Physiology-Endocrinology and Metabolism 295, E1462-E1479, 2008
  • Giang D.V., Lenbury Y., Andrea De Gaetano, Pasquale Palumbo: Delay models of glucose-insulin systems: global stability and oscillated solutions conditional on delays, Journal of Mathematical Analysis and Applications 343, 996-1006, 2008
  • Morganti A., Deodato F., Zizzari S., Cilla S., Digesù C., Macchia G., Simona Panunzi, Andrea De Gaetano, Piermattei A., Cellini N., Valentini V.: Complexity Index (COMIX) and Not Type of Treatment Predicts Undetected Errors in Radiotherapy Planning and Delivery., Radiotherapy Oncology 89, 320-329, 2008
  • Pasquale Palumbo, Picchini U., Beck B., van Gelder J., Delbar N., Andrea De Gaetano: A general approach to the apparent permeability index, Journal of Pharmacokinetics and Pharmacodynamics 35, 235-248, 2008
  • Picchini U., Ditlevsen S., Andrea De Gaetano: Maximum Likelihood Estimation of a Time-Inhomogeneous Stochastic Differential Model of Glucose Dynamics., Mathematical Medicine and Biology 25, 141-155, 2008
  • Picchini U., Ditlevsen S., Andrea De Gaetano, Lansky P.: Parameters of the Diffusion Leaky Integrate-and-Fire Neuronal Model for a Slowly Fluctuating Signal., Neural Computation 20, 2696-2714, 2008
  • Pasquale Palumbo, Andrea De Gaetano: State-feedback control of the glucose-insulin system, in: Math Everywhere: Deterministic and Stochastic Modelling in Biomedicine, Economics and Industry, Aletti G., Burger M., Micheletti A., Morale D. eds., Springer Heidelberg, 241-252, 2007
  • Pasquale Palumbo, Simona Panunzi, Andrea De Gaetano: Qualitative behavior of a family of delay-differential models of the glucose-insulin system, Discrete and Continuous Dynamical Systems-Series B 7 (2), 399-424, 2007
  • Simona Panunzi, Pasquale Palumbo, Andrea De Gaetano: A discrete single-delay model for the Intra-Venous Glucose Tolerance Test, Theoretical Biology and Medical Modelling 4 (35), 2007
  • Rusciani L., Proietti I., Paradisi A., Rusciani A., Guerriero G., Mammone A., Andrea De Gaetano, Lippa S.: Recombinant interferon alpha-2b and coenzyme Q10 as a postsurgical adjuvant therapy for melanoma: a 3-year trial with recombinant interferon-alpha and 5-year follow-up, Melanoma Research 17, 177-183, 2007
  • Clausen W.H.O., Andrea De Gaetano, Vòlund A.: Within-patient variation of the pharmacokinetics of subcutaneously injected biphasic insulin aspart as assessed by compartmental modelling, Diabetologia 49 (9), 2030-2038, 2006
  • Andrea De Gaetano, Simona Panunzi, Beck B., Boulanger B.: Statistical Modeling in Pharmaceutical Research \& Development, in: Computers in Drug Discovery, Ekins S. ed., John Wiley, 2006
  • Morelli A., Teboul J.L., Maggiore S.M., Vieillard-Baron A., Rocco M., Conti G., Andrea De Gaetano, Picchini U., Orecchioni A., Carbone I., Pietropaoli P., Westphal M.: Effects Of Levosimendan On Right Ventricular Afterload In Patients With Acute Respiratory Distress Syndrome: A Pilot Study, Critical Care Medicine 34 (9), 2287-2293, 2006
  • Pasquale Palumbo, Ong-Clausen W.H., Simona Panunzi, Andrea De Gaetano: Linear periodic models of subcutaneous insulin absorption: mathematical analysis, HERMIS Journal 7, 60-79, 2006
  • Pavoni E., Pucci A., Vaccaro P., Monteriu G., Ceratti Ade P., Lugini A., Virdis R.A., Cortesi E., Andrea De Gaetano, Simona Panunzi, Felici F., Minenkova O.: A study of the humoral immune response of breast cancer patients to a panel of human tumor antigens identified by phage display, Cancer Detection and Prevention 30 (3), 248-256, 2006
  • Picchini U., Andrea De Gaetano, Ditlevsen S.: Parameter estimation in stochastic differential mixed-effects models, Department of Biostatistics, University of Copenhagen, 6, 2006
  • Picchini U., Ditlevsen S., Andrea De Gaetano: Modeling the euglycemic hyperinsulinemic clamp by stochastic differential equations, Journal of Mathematical Biology 53 (5), 771-796, 2006
  • Rusciani L., Proietti I., Rusciani A., Paradisi A., Sbordoni G., Alfano C., Simona Panunzi, Andrea De Gaetano, Lippa S.: Low plasma coenzyme Q10 levels as an independent prognostic factor for melanoma progression, Journal of the American Academy of Dermatology 54 (2), 234-241, 2006
  • Ciampelli M., Leoni F., Cucinelli F., Mancuso S., Simona Panunzi, Andrea De Gaetano, Lanzone A.: Assessment of Insulin Sensitivity From Measurements in the Fasting State and During an Oral Glucose Tolerance Test in Polycystic Ovary Syndrome and Menopausal Patients, Journal of Clinical Endocrinology and Metabolism 90, 1398-1406, 2005
  • Clausen W.H.O., Andrea De Gaetano: A model for exhogenous glucose regulation in IDDM, in the Proceedings of European Conference on Mathematical and Theoretical Biology, 2005
  • Andrea De Gaetano, Simona Panunzi: Nonlinear Estimation and Confidence Regions: a Biological Case Study, in: Mathematical Models for Bioengineering and Probabilistic Systems, Misra J.C. ed., Narosa, New Delhi, 2005
  • Ditlevsen S., Andrea De Gaetano: Stochastic Vs. Deterministic Uptake of Dodecanedioic Acid by Isolated Rat Livers, Bulletin of Mathematical Biology 67, 547-561, 2005
  • Morelli A., Ricci Z., Bellomo R., Ronco C., Rocco M., Conti G., Andrea De Gaetano, Picchini U., Orecchioni A., Portieri M., Coluzzi F., Porzi P., Serio P., Bruno A., Pietropaoli P.: Prophylactic Fenoldopam for Renal Protection in Sepsis: a Randomized, Double-Blind, Placebo-Controlled Pilot Trial, Critical Care Medicine 33, 2451-2456, 2005
  • Morelli A., Tritapepe L., Rocco M., Conti G., Orecchioni A., Andrea De Gaetano, Picchini U., Pelaia P., Reale C., Pietropaoli P.: Terlipressin Versus Norepinephrine to Counteract Anesthesia-Induced Hypotension in Patients Treated With Renin-Angiotensin System Inhibitors: Effects on Systemic and Regional Hemodynamics, Anesthesiology 102, 12-19, 2005
  • Simona Panunzi, Andrea De Gaetano, Mingrone G.: Approximate Linear Confidence and Curvature of a Kinetic Model of Dodecanedioic Acid in Humans, American Journal of Physiology-Endocrinology and Metabolism, 2005
  • Picchini U., Andrea De Gaetano, Ditlevsen S.: System noise modelization in glucose-insulin dynamics, IASI-CNR, R. 630, 2/2005
  • Picchini U., Andrea De Gaetano, Simona Panunzi, Ditlevsen S., Mingrone G.: A mathematical model of the euglycemic hyperinsulinemic clamp, Theoretical Biology and Medical Modelling 2, 2005
  • Ciampelli M., Leoni F., Cucinelli F., Mancuso S., Simona Panunzi, Andrea De Gaetano, Lanzone A.: Assessment of Insulin Sensitivity From Measurements in the Fasting State and During an Oral Glucose Tolerance Test in Polycystic Ovary Syndrome and Menopausal Patients., Journal of Clinical Endocrinology and Metabolism, 2004
  • Morelli A., Rocco M., Conti G., Orecchioni A., Andrea De Gaetano, Coluzzi F., Vernaglione E., Pelaia P., Pietropaoli P.: Effects of Short-Term Fenoldopam Infusion on Gastric Mucosal Blood Flow in Septic Shock., Anesthesiology 101, 576-582, 2004
  • Morelli A., Rocco M., Conti G., Orecchioni A., Andrea De Gaetano, Cortese G., Coluzzi F., Vernaglione E., Pelaia P., Pietropaoli P.: Effects of Terlipressin on Systemic and Regional Haemodynamics in Catecholamine-Treated Hyperkinetic Septic Shock., Intensive Care Medicine 30, 597-604, 2004
  • Mukhopadhyay A., Andrea De Gaetano, Arino O.: Modelling the Intra-Venous Glucose Tolerance Test: a Global Study for a Single-Distributed-Delay Model., Discrete and Continuous Dynamical Systems-Series B, 2004
  • Andrea De Gaetano, Di Martino D., Germani A., Costanzo Manes: Distributed-delays models of the glucose-insulin homeostasis and asymptotic state observations, IASI-CNR, R. 604, 00/2003
  • Andrea De Gaetano, Di Martino D., Germani A., Costanzo Manes: Mathematical models and state observation of the glucose-insulin homeostasis, in the Proceedings of 21st IFIP TC 7 Conference on System Modeling and Optimization, Sophia Antipolis, France, 2003
  • Andrea De Gaetano, Giorgi A., Risi A., Sciandrone M.: A patient adaptable ECG beat classifier based on neural networks, IASI-CNR, R. 588, 06/2003
  • Ditlevsen S., Andrea De Gaetano: A Model of the Uptake of Alternative Fatty Acids by Isolated Rat Liver Based on Stochastic Differential Equations, in the Proceedings of Workshop on Dynamical Stochastic Modeling in Biology, 8--10 January 2003, Huebner M., Sorensen M. eds., 2003
  • Gasbarrini G., Mingrone G., Giancaterini A., Andrea De Gaetano, Scarfone A., Capristo E., Calvani M., Caso V., Greco A.V.: Effects of Propionyl-L-Carnitine Topical Irrigation in Distal Ulcerative Colitis: a Preliminary Report, Hepato-Gastroenterology 50, 1385-1389, 2003
  • Muretto P., Graziano F., Staccioli M.P., Barbanti I., Bartolucci A., Paolini G., Giordano D., Testa E., Andrea De Gaetano: An Endogastric Capsule for Measuring Tumor Markers in Gastric Juice: an Evaluation of the Safety and Efficacy of a New Diagnostic Tool, Annals of Oncology 14, 105-109, 2003
  • Ruzzo A., Graziano F., Costagliola A., Arduini F., Testa E., Bearzi I., Cortese G., Andrea De Gaetano, Andreoni F., Lai V., Magnani M.: The G/A Nucleotide Change at CDNA Position 2494 in the E-Cadherin Gene (CDH1): Analysis in Italian Patients, Tumour Biology 24, 147-150, 2003
  • Severini M., Dattilo A.M., Andrea De Gaetano: Sublethal Effect of a Weak Intermittent Magnetic Field on the Development of Xenopus Laevis (Daudin) Tadpoles, International Journal of Biometeorology, 2003
  • Graziano F., Bisonni R., Catalano V., Silva R., Rovidati S., Mencarini E., Ferraro B., Canestrari F., Baldelli A.M., Andrea De Gaetano, Giordani P., Testa E., Lai V.: Potential role of levocarnitine supplementation for the treatment of chemotherapy-induced fatigue in non-anaemic cancer patients, British Journal of Cancer 86 (12), 1854-1857, 2002
  • Gui D., Runfola M., Rossi S., Simona Panunzi, Andrea De Gaetano: Academic recruitment in Spain and Italy, Science 297 (5582), 770-771, 2002
  • Marino S., Andrea De Gaetano, Giancaterini A., Giordano D., Manco M., Greco A.V., Mingrone G.: Computing DIT from energy expenditure measures in a respiratory chamber: a direct modeling method, Computers in Biology and Medicine 32 (4), 297-309, 2002
  • Gui D., Andrea De Gaetano, Spada P.L., Viggiano A., Cassetta E., Albanese A.: Botulinum toxin injected in the gastric wall reduces body weight and food intake in rats., Alimentary Pharmacology & Therapeutics 14 (6), 829-34, 2000
  • Mingrone G., Andrea De Gaetano, Greco A.V., Capristo E., Benedetti G., Castagneto M., Gasbarrini G.: Comparison between dodecanedioic acid and long-chain triglycerides as an energy source in liquid formula diets, Journal of Parenteral and Enteral Nutrition 23 (2), 80-4, 1999
  • Alessandro Bertuzzi, Mingrone G., Andrea De Gaetano, Alberto Gandolfi, Greco A.V., Salinari S.: Kinetics of dodecanedioic acid and effect of its administration on glucose kinetis in rats, British Journal of Nutrition 78, 143-153, 1997
  • Mingrone G., Andrea De Gaetano, Greco A.V., Capristo E., Benedetti G., Castagneto M., Gasbarrini G.: Dodecanedioic acid infusion induces a sparing effect on whole-body glucose uptake, mainly in non-insulin-dependent diabetes mellitus, British Journal of Nutrition 78 (5), 723-35, 1997
  • Mingrone G., Andrea De Gaetano, Greco A.V., Capristo E., Benedetti G., Castagneto M., Gasbarrini G.: Reversibility of insulin resistance in obese diabetic patients: role of plasma lipids, Diabetologia 40 (5), 599-605, 1997
  • Gui D., Spada P.L., Andrea De Gaetano: Hypocholesterolemia and risk of death in the critically-ill surgical patients, Intensive Care Medicine 22, 790-794, 1996
  • Mingrone G., Andrea De Gaetano, Greco A.V., Benedetti G., Capristo E., Castagneto M., Gasbarrini G.: Plasma clearance and oxidation of dodecanedioic acid in humans, Journal of Parenteral and Enteral Nutrition 20 (1), 38-42, 1996
  • Mingrone G., Andrea De Gaetano, Greco A.V., Capristo E., Castagneto M., Gasbarrini G.: Medium-chain triglycerides for parenteral nutrition: kinetic profile in humans, Nutrition 11 (5), 418-22, 1995
  • Coleman W.P., Andrea De Gaetano, Brugnoli P., Gui D., Giovannini I., Castagneto M., Siegel J.H.: Mathematical techniques for investigating respiratory control, in: Modeling and Control in Biomedical Systems, Patterson B.W. ed., University of Texas Galveston, 550-551, 1994
  • Andrea De Gaetano, Castagneto M., Mingrone G., Gangeri G., Gabriele Sganga, Tataranni P.A., Raguso C., Greco A.V.: Kinetics of medium-chain triglycerides and free fatty acids in healthy volunteers and surgically stressed patients, Journal of Parenteral and Enteral Nutrition 18 (2), 134-40, 1994
  • Mingrone G., Greco A.V., Andrea De Gaetano, Tataranni P.A., Raguso C., Castagneto M.: Pharmacokinetic profile of dodecanedioic acid, a proposed alternative fuel substrate, Journal of Parenteral and Enteral Nutrition 18 (3), 225-30, 1994
  • Raguso C., Mingrone G., Greco A.V., Tataranni P.A., Andrea De Gaetano, Castagneto M.: Dicarboxylic acids and glucose utilization in humans: effect of sebacate, Journal of Parenteral and Enteral Nutrition 18 (1), 9-13, 1994
  • Alessandro Bertuzzi, Andrea De Gaetano, Alberto Gandolfi, Greco A.V., Mingrone G., Salinari S.: Pharmacokinetics of Dodecanedioic Acid in Rat, in the Proceedings of 15th International Conference of IEEE-EMBS, San Diego, Szeto A.Y.J., Rangayyan R.M. eds., IEEE New York, 572-573, 1993
  • Coleman W.P., Siegel J.H., Giovannini I., Sanford D.P., Andrea De Gaetano: Computational logic: a method for formal analysis of the ICU knowledge base, International Journal of Clinical Monitoring and Computing 10, 67-79, 1993
  • Mingrone G., Greco A.V., Castagneto M., Andrea De Gaetano, Tataranni P.A., Raguso C.: Kinetics and thermogenesis of medium-chain monocarboxylic and dicarboxylic acids in man: sebacate and medium-chain triglycerides, Journal of Parenteral and Enteral Nutrition 17 (3), 257-64, 1993
  • Greco A.V., Mingrone G., Raguso C., Tataranni P.A., Finotti E., Tacchino R.M., Capristo E., Andrea De Gaetano, Castagneto M.: Metabolic effects and disposition of sebacate, an alternate dicarboxylic fuel substrate, Annals of Nutrition and Metabolism 36 (1), 1-11, 1992
  • Coleman W.P., Siegel J.H., Giovannini I., Andrea De Gaetano, Goodarzi S., Tacchino R.M., Gabriele Sganga: Probability and the patient state space, International Journal of Clinical Monitoring and Computing 7, 201-215, 1990
  • Laghi F., Siegel J.H., Rivkind A.I., Carlo Chiarla, Andrea De Gaetano, Blevins S., Stoklosa J.C., Borg U.R., Belzberg H.: Respiratory index/pulmonary shunt relationship: quantification of severity and prognosis in the post-traumatic adult respiratory distress syndrome, Critical Care Medicine 17 (11), 1121-1128, 1989
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