PATHOPHYSIOLOGY, METABOLISM AND IMMUNOLOGY

The research activity is directed to the study of the mechanisms of biologic and pathophysiologic changes and adaptive mechanisms in critical illness, from compensated stages to extreme conditions of non-equilibrium, with particular attention to severe trauma, major surgical procedures, shock and sepsis. A practical implication is the optimization of metabolic and cardiorespiratory therapy.


Research topics
PATHOPHYSIOLOGY OF SEPSIS AND TRAUMA

Metabolic control in different stages of disease, and mechanism of survival in extreme condition. Early recognition of prognostic indicators following major surgical procedures. Impact of specific nutritional substrates, mainly amino acids and lipids, on metabolic regulation and cellular protection in human critical illness. Endothelial damage and genic modulation of cytokines in trauma, sepsis and multiple organ failure.


GASTRO-INTESTINAL MOTILITY

Inhibition of motility; effects of botulinum toxin.


BIOMATERIALS

Physical and structural stability; long term central venous access.


IMMUNOMODULATION

Cellular and molecular immune response; cell cooperation, immunosuppressive drugs, specific peptides, growth factors.


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