Starting from the human genome sequencing, in the last fifteen years there was a dramatic increase of connections between mathematics, statistics, computer science and biology to analyze the amount of information related to genes and proteins and the  interactions between different molecules. New insight is required of mathematical methods for representing and simulating biological complex systems. The Computational and Systems Biology Group of IASI has been created in 2005.

Reverse engineering; cell cycle modeling; functional modules-based analysis; circuits in biochemical networks; system-level properties.

Algorithms for haplotyping problems; Tag SNP prediction; biodiversity and barcode analysis; gene expression microarray data analysis; protein  structure comparison and alignment; data mining techniques for biological problems.