Pasquale Palumbo
Pasquale Palumbo Pasquale Palumbo
Research Associate
PhD in Electronic Engineering

Dipartimento di Biotecnologie e Bioscienze - Universita' degli Studi di Milano-Bicocca
.
20100 Milano - Italy

Personal web page: http://www.iasi.cnr.it/~palumbo/

Research interests

STATE ESTIMATION AND FILTERING: linear and nonlinear systems, non-Gaussian systems, descriptor systems, switching systems

MATHEMATICAL MODELS IN BIOLOGY AND MEDICINE: the glucose/insulin regulatory system, glucose control, systems biology, the immune system, pharmacokinetics and pharmacodynamics

MODELING AND CONTROL OF FLEXIBLE SYSTEMS

STOCHASTIC CONTROL


Research groups

Selected publications
  • Pasquale Palumbo, Federico Papa, Vanoni M., Alberghina L.: Qualitative behavior of a coarse-grain growth model, presented at INES 2019, 2019
  • Pola G., Alessandro Borri, Pepe P., Pasquale Palumbo, Di Benedetto M. D.: Symbolic models approximating possibly unstable time-delay systems with application to the artificial pancreas, Proceedings of the 2019 European Control Conference (ECC 2019), Napoli, Italy, pp. 275-280, 2019
  • Alessandro Borri, Pasquale Palumbo, Singh A: Noise propagation in feedback coupling between cell growth and metabolic activity, Proceedings of the 57th IEEE Conference on Decision and Control (CDC 2018), Miami Beach, FL, USA, pp. 2679-2684, 2018
  • Cacace F., Valerio Cusimano, Germani A., Pasquale Palumbo, Federico Papa: Closed-loop control of tumor growth by means of anti-angiogenic administration, Mathematical Biosciences and Engineering 15, 827-839, 2018
  • Pasquale Palumbo, Federico Papa: Mathematical Modeling in Systems Biology, Minisymposium at SIMAI 2018, 2018
  • Pasquale Palumbo, Vanoni M., Federico Papa, Busti S, Wortel M., Teusink B, Alberghina L.: An integrated model of metabolism, growth and cell cycle in budding yeast, presented at SIMAI 2018, 2018
  • Pasquale Palumbo, Vanoni M., Federico Papa, Busti S, Wortel M., Teusink B, Alberghina L.: An integrated model quantitatively describing metabolism, growth and cell cycle in budding yeast, Communications in Computer and Information Science, Artificial Life and Evolutionary Computation, 12th Italian Workshop, WIVACE 2017, Venice, Italy, September 19-21, 2017, Revised Selected Papers, 2018
  • Pasquale Palumbo, Vanoni M., Federico Papa, Busti S., Alberghina L.: Whole yeast model: what and why?, presented at Bioinformatics and Computational Biology International Conference 2018, 2018
  • Alessandro Borri, Cacace F., De Gaetano A., Germani A., Manes C., Pasquale Palumbo, Simona Panunzi, Pepe P.: Luenberger-Like Observers for Nonlinear Time-Delay Systems with Application to the Artificial Pancreas: The Attainment of Good Performance, IEEE Control Systems Magazine 37(4), pp. 33-49, 2017
  • Alessandro Borri, Pasquale Palumbo, Manes C., Simona Panunzi, De Gaetano A.: Sampled-data Observer-based Glucose Control for the Artificial Pancreas, Acta Polytechnica Hungarica vol. 14, p. 79-94, 2017
  • Alessandro Borri, Pasquale Palumbo, Singh A: Noise propagation in a class of metabolic networks, Proceedings of the 56th IEEE Conference on Decision and Control (CDC 2017), Melbourne, Australia, pp. 447-452, 2017
  • Gaz C., De Gaetano A., Manes C., Pasquale Palumbo, Alessandro Borri, Simona Panunzi: Effective Control of Glycemia using a Simple Discrete-delay Model, IFAC-PapersOnLine, Volume 50, Issue 1, Pages 13526-13531, 2017
  • Pasquale Palumbo, Vanoni M., Federico Papa, Busti S, Wortel M., Teusink B, Alberghina L.: An integrated metabolism, growth and cell cycle model quantitatively describing budding yeast growth, presented at WIVACE 2017, 2017
  • Pires JG, Alessandro Borri, De Gaetano A., Manes C., Pasquale Palumbo: A short-term dynamical model for ghrelin, IFAC-PapersOnLine, Volume 50, Issue 1, Pages 11011-11016, 2017
  • Borri A, Francesco Carravetta, Pasquale Palumbo: Cubification of Nonlinear Stochastic Differential Equations and Approximate Moments Calculation of the Langevin Equation, 55th IEEE Conference on Decision and Control (CDC16), 2016
  • Borri A, Pasquale Palumbo, Singh A: Noise reduction for enzymatic reactions: a case study for stochastic product clearance, 55th IEEE Conference on Decision and Control (CDC16), 2016
  • Borri A, Pasquale Palumbo, Singh A: The impact of negative feedback in metabolic noise propagation, IET Systems Biology 10, 179-186, 2016
  • Borri A, Simona Panunzi, Pasquale Palumbo, Manes C., De Gaetano A.: Glucose control with incomplete information, IEEE Conference on Systems, Man and Cybernetics, 2016
  • Borri A., Francesco Carravetta, Gabriella Mavelli, Pasquale Palumbo: Block-tridiagonal state-space realization of Chemical Master Equations: a tool to compute explicit solutions, Journal of computational methods in applied mathematics 296, 410-426, 2016
  • Alessandro Borri, Francesco Carravetta, Gabriella Mavelli, Pasquale Palumbo: Block-tridiagonal state-space realization of Chemical Master Equations: A tool to compute explicit solutions, Journal of Computational and Applied Mathematics vol. 296, pp. 410–426, 2016
  • Alessandro Borri, Francesco Carravetta, Pasquale Palumbo: A Cubification Approach for the Approximate Moments Computation in Stochastic Differential Equations: Application to the Chemical Langevin Equation, IASI-CNR, R. 16-01, 2016
  • Alessandro Borri, Francesco Carravetta, Pasquale Palumbo: Stochastic Differential Equations and Approximate Moments Calculation of the Langevin Equation, Proceedings of the 55th IEEE Conference on Decision and Control (CDC 2016), Las Vegas, USA, pp. 4540-4545, 2016
  • Alessandro Borri, Pasquale Palumbo, Singh A: Impact of negative feedback in metabolic noise propagation, IET Systems Biology 10 (5), 179-186, 2016
  • Alessandro Borri, Pasquale Palumbo, Singh A: Noise reduction for enzymatic reactions: a case study for stochastic product clearance, Proceedings of the 55th IEEE Conference on Decision and Control (CDC 2016), Las Vegas, USA, pp. 5851-5856, 2016
  • Alessandro Borri, Simona Panunzi, Pasquale Palumbo, Manes C., De Gaetano A.: Glucose control with incomplete information, Proceedings of the 2016 IEEE International Conference on Systems, Man, and Cybernetics (SMC 2016), Budapest, Ungheria, pp. 1780-1784, 2016
  • Alessandro Borri, Simona Panunzi, Pasquale Palumbo, Manes C., De Gaetano A.: Preliminary results on glucose control with sampled information, IASI-CNR, R. 16-02, 2016
  • Cacace F., Valerio Cusimano, Germani A., Pasquale Palumbo: A state predictor for continuous-time stochastic systems, Systems & Control Letters 98, 37-43, 2016
  • Cacace F., Valerio Cusimano, Germani A., Pasquale Palumbo: Carleman discretization of impulsive systems: application to the optimal control problem of anti-angiogenic tumor therapies, 55th IEEE Conference on Decision and Control (CDC16), 2016
  • Valerio Cusimano, Pasquale Palumbo, Federico Papa: Closed-loop control of tumor growth by means of anti-angiogenic administration, presented at SIMAI 2016, 2016
  • Pasquale Palumbo, Vanoni M., Valerio Cusimano, Busti S, Marano M., Manes C., Alberghina L.: Whi5 phosphorylation embedded in the G1/S network dynamically controls critical cell size and cell fate, Nature Communications, 2016
  • Alessandro Borri, Pasquale Palumbo, Singh A: Metabolic noise reduction for enzymatic reactions: the role of a negative feedback, Proceedings of the 54th IEEE Conference on Decision and Control (CDC 2015), Osaka, Giappone, pp. 2537–2542, 2015
  • Valerio Cusimano, Pasquale Palumbo, Federico Papa: Closed-loop control of tumor growth by means of anti-angiogenic administration, IEEE 54th Annual Conference on Decision and Control (CDC 2015), 2015
  • Pasquale Palumbo, Vanoni M., Federico Papa, Alberghina L.: A Growth and Cycle Model for Saccharomyces cerevisiae, presented at 27th International Conference on Yeast Genetics and Molecular Biology, poster session, 2015
  • Federico Papa, Pasquale Palumbo, Vanoni M., Wortel M., Teusink B, Alberghina L.: An Integrated Metabolism, Growth and Cycle Model for Saccharomyces cerevisiae: Validation against Chemostat Data, presented at 27th International Conference on Yeast Genetics and Molecular Biology, poster session, 2015
  • Vanoni M., Pasquale Palumbo, Federico Papa, Busti S., Wortel M., Teusink B, Alberghina L.: An integrated metabolism, growth and cycle model for Saccharomyces cerevisiae, presented at 27th International Conference on Yeast Genetics and Molecular Biology, 2015
  • Bersani A, Alessandro Borri, Francesco Carravetta, Gabriella Mavelli, Pasquale Palumbo: Quasi-Steady-State Approximations of the Chemical Master Equation in Enzyme Kinetics - Application to the Double Phosphorylation/ Dephosphorylation Cycle, in the Proceedings of Decision and Control (CDC), 2014 IEEE 53rd Annual Conference on, IEEE Conference on Decision and Control (CDC 2014), 2014
  • Cacace F., Valerio Cusimano, Alfredo Germani, Pasquale Palumbo: A Carleman discretization approach to filter nonlinear stochastic systems with sampled measurements, IFAC World Congress on Automatic Control, 2014
  • Francesco Carravetta, Manes C., Pasquale Palumbo: Filtering and parameter estimation for a class of Hidden Markov Models with application to bubble-counting in microfluidics, IFAC World Congress on Automatic Control, 2014
  • De Gaetano A., Simona Panunzi, Pasquale Palumbo, Gaz C., Hardy T.: Data-driven modeling of diabetes progression, in: Data-driven models for Diabetes. Diagnosis and Treatment, Mitsis G, Marmarelis V eds., Lecture Notes in Bioengineering, Springer-Verlag Berlin Heidelberg, 165-186, 2014
  • Kong J.D., Kumar S.S., Pasquale Palumbo: DDE models of the glucose-insulin system: a useful tool for the artificial pancreas, in: Managing Complexity, Reducing Perplexity in Biological Systems, Ajomne-Marsan G, Delitala M eds., Proceedings in Mathematics and Statistics, 67, Springer, 109-117, 2014
  • Pasquale Palumbo, Pepe P., Simona Panunzi, De Gaetano A.: DDE model-based control of glycemia via sub-cutaneous insulin administration, in: Delay Systems. From Theory to Numerics and Applications, Sipahi R, Vyhlidal T, Lafay J-F eds., Advances in Delays and Dynamics, 1, Springer International Publishing, 229-240, 2014
  • Pasquale Palumbo, Pizzichelli G, Simona Panunzi, Pepe P., De Gaetano A.: Closed-loop control scheme for the euglycemic hyperinsulinemic clamp: validation on virtual patients, IFAC World Congress on Automatic Control, 2014
  • Pasquale Palumbo, Pizzichelli G, Simona Panunzi, Pepe P., De Gaetano A.: Model-based control of plasma glycemia: Tests on populations of virtual patients, Mathematical Biosciences 257, 2-10, 2014
  • Simona Panunzi, Alessandro Borri, Pasquale Palumbo, Kovacs L, De Gaetano A.: Simulation of insulin regimen and glucose profiles in Type 1 Diabetic Patient, IEEE Conference on Systems, Man and Cybernetics, San Diego, USA, pp. 2464-2469, 2014
  • Tasdighian S, Di Paola L, De Ruvo M, Paola Paci, Daniele Santoni, Pasquale Palumbo, Mei G, Di Venere A, Giuliani A: Modules identification in protein structures: the topological and geometrical solutions, Journal of Chemical Information and Modeling, 54(1): 159-168, 2014
  • Alessandro Borri, Francesco Carravetta, Gabriella Mavelli, Pasquale Palumbo: Chemical Master Equations: a mathematical scheme for the multi-site phosphorylation case, Proceedings of the 3rd International Conference on Simulation and Modeling Methodologies, Technologies and Applications (SIMULTECH 2013), Reykjavik, Iceland, pp. 681-688, 2013
  • Alessandro Borri, Francesco Carravetta, Gabriella Mavelli, Pasquale Palumbo: Some Results on the structural properties and the solution of the Chemical Master Equation, Proceedings of the 2013 American Control Conference (ACC 2013), Washington, DC, USA, pp. 3777-3782, 2013
  • Cacace F., Alfredo Germani, Pasquale Palumbo: The Observer Follower Filter: a new approach to nonlinear suboptimal filtering, Automatica 49(2), 548-553, 2013
  • Francesco Carravetta, Pasquale Palumbo, Pepe P.: Memoryless solution to the optimal control problem for linear systems with delayed input, Kybernetika 49, 568-589, 2013
  • Pasquale Palumbo, Ditlevsen S., Bertuzzi A., De Gaetano A.: Mathematical modeling of the glucose-insulin system: a review, Mathematical Biosciences 244, 69-81, 2013
  • Pasquale Palumbo, Pepe P., Simona Panunzi, De Gaetano A.: Observer-based closed-loop control for the glucose-insulin system: local Input-to-State Stability with respect to unknown meal disturbances, American Control Conference (ACC13), 2013
  • Alberghina L., Gabriella Mavelli, Drovandi G., Pasquale Palumbo, Pessina S., Tripodi F., Coccetti P., Vanoni M.: Cell growth and cell cycle in Saccharomyces cerevisiae: Basic regulatory design and protein - protein interaction network, Biotechnology Advances 30, 52-72, 2012
  • Alessandro Borri, Francesco Carravetta, Gabriella Mavelli, Pasquale Palumbo: A study on the structural properties and the solution of the Chemical Master Equation, IASI-CNR, R. 12-10, 10/2012
  • Cacace F., Alfredo Germani, Pasquale Palumbo: The Observer Follower Filter: a new approach to nonlinear suboptimal filtering, Automatica, 2012
  • Cacace F., Alfredo Germani, Pasquale Palumbo: The state observer as a tool for the estimation of gene expression, Journal of Mathematical Analysis and Applications 391, 382-396, 2012
  • Francesco Carravetta, Pasquale Palumbo, Pepe P.: Memoryless solution to the infinite horizon optimal control of linear time-invariant systems with delayed input, IASTED Asian Conference on Modeling, Identification and Control (AsiaMIC2012), 2012
  • De Gaetano A., Matone A., Agnes A.M., Pasquale Palumbo, Ria F., Magalini S.: Modeling rejection immunity, Theoretical Biology and Medical Modelling 9, 2012
  • Li J., Wang M., De Gaetano A., Pasquale Palumbo, Simona Panunzi: The range of time delay and the global stability of the equilibrium for an IVGTT model., Mathematical Biosciences 235, 128-137, 2012
  • Pasquale Palumbo, Pepe P., Simona Panunzi, De Gaetano A.: Observer-based glucose control via subcutaneous insulin administration, 8th IFAC Symposium on Biological and Medical Systems (BMS2012), 2012
  • Pasquale Palumbo, Pepe P., Simona Panunzi, De Gaetano A.: Time-delay model-based control of the glucose-insulin system, by means of a state observer, European Journal of Control, 2012
  • Cacace F., Alfredo Germani, Pasquale Palumbo: A new approach to nonlinear filtering via a mixed state observer and polynomial Kalman-Bucy scheme, in the Proceedings of 18th, IFAC World Congress on Automatic Control, 2011
  • Cacace F., Alfredo Germani, Pasquale Palumbo: A state observer approach to filter stochastic nonlinear differential systems, 50th IEEE Conference on Decision and Control & 11th European Control Conference (CDC-ECC 2011), 2011
  • Pasquale Palumbo, Pepe P., Simona Panunzi, De Gaetano A.: Glucose control by subcutaneous insulin administration: a DDE modelling approach, in the Proceedings of 18th, IFAC World Congress on Automatic Control, 2011
  • Pasquale Palumbo, Pizzichelli G, Simona Panunzi, Pepe P., De Gaetano A.: Tests on a virtual patient for an observer-based, closed-loop control of plasma glycemia, 50th IEEE Conference on Decision and Control & 11th European Control Conference (CDC-ECC 2011), 2011
  • Farina L., Alfredo Germani, Gabriella Mavelli, Pasquale Palumbo: Identification of regulatory network motifs from gene expression data, Journal of Mathematical Modelling and Algortihms 9, 233-245, 2010
  • Alfredo Germani, Manes C., Pasquale Palumbo: Representation of a class of MIMO systems via internally positive realization, European Journal of Control 16(3), 291-304, 2010
  • Gabriella Mavelli, Pasquale Palumbo: The Carleman approximation approach to solve a stochastic nonlinear control problem, IEEE Transactions on Automatic Control 55(4), 976-982, 2010
  • Pasquale Palumbo, De Gaetano A.: An islet population model of the endocrine pancreas, Journal of Mathematical Biology 61(2), 171-205, 2010
  • Pasquale Palumbo, Gabriella Mavelli, Farina L., Alberghina L.: Networks and circuits in cell regulation, Biochemical and Biophysical Research Communications 396, 881-886, 2010
  • Cacace F., Alfredo Germani, Pasquale Palumbo: Observer-based identification of a multi-output feedforward loop from gene expression data, 48th Conference on Decision and Control (CDC2009) held jointly with 2009 28-th Chinese Control Conference, 2009
  • Alfredo Germani, Manes C., Pasquale Palumbo: State estimation of stochastic systems with switching measurements: a polynomial approach, International Journal of Robust and Nonlinear Control 19, 1632-1655, 2009
  • Pasquale Palumbo, Pepe P., Simona Panunzi, De Gaetano A.: Robust closed-loop control of plasma glycemia: a discrete-delay model approach, Discrete and Continuous Dynamical Systems-Series B Special Issue on Mathematical Biology and Medicine, 455-468, 2009
  • Francesco Carravetta, Pasquale Palumbo, Giovanni Felici: Regulation of a Manned Sea-Surface Vehicle via Stochastic Optimal Control., in the Proceedings of 17th IFAC World Congress on Automatic Control (IFAC2008), 2008
  • De Gaetano A., Hardy T., Beck B., Abu-Raddad E., Pasquale Palumbo, Blu-Valleskey J., Porksen N.: Mathematical models of diabetes progression, American Journal of Physiology-Endocrinology and Metabolism 295, E1462-E1479, 2008
  • Giang D.V., Lenbury Y., De Gaetano A., Pasquale Palumbo: Delay models of glucose-insulin systems: global stability and oscillated solutions conditional on delays, Journal of Mathematical Analysis and Applications 343, 996-1006, 2008
  • Pasquale Palumbo, Picchini U., Beck B., van Gelder J., Delbar N., De Gaetano A.: A general approach to the apparent permeability index, Journal of Pharmacokinetics and Pharmacodynamics 35, 235-248, 2008
  • Alfredo Germani, Manes C., Pasquale Palumbo: Filtering of stochastic nonlinear differential systems via a Carleman approximation approach, IEEE Transactions on Automatic Control 52 (11), 2166-2172, 2007
  • Manes C., Martinelli A., Martinelli F., Pasquale Palumbo: Mobile robot localization based on a polynomial approach, in the Proceedings of IEEE International Conference on Robotics and Automation (ICRA'07), 3539-3544, 2007
  • Pasquale Palumbo, De Gaetano A.: State-feedback control of the glucose-insulin system, in: Math Everywhere: Deterministic and Stochastic Modelling in Biomedicine, Economics and Industry, Aletti G., Burger M., Micheletti A., Morale D. eds., Springer Heidelberg, 241-252, 2007
  • Pasquale Palumbo, Simona Panunzi, De Gaetano A.: Qualitative behavior of a family of delay-differential models of the glucose-insulin system, Discrete and Continuous Dynamical Systems-Series B 7 (2), 399-424, 2007
  • Simona Panunzi, Pasquale Palumbo, De Gaetano A.: A discrete single-delay model for the Intra-Venous Glucose Tolerance Test, Theoretical Biology and Medical Modelling 4 (35), 2007
  • Di Martino D., Alfredo Germani, Manes C., Pasquale Palumbo: Design of observers for systems with rational output function, in the Proceedings of 45th IEEE Conference on Decision and Control (CDC06), Parisini T. ed., 1641-1646, 2006
  • Alfredo Germani, Graziosi F., Manes C., Ocera G., Pasquale Palumbo: Recursive filtering for log-Rice signals, in the Proceedings of 45th IEEE Conference on Decision and Control (CDC06), Parisini T. ed., 2006
  • Alfredo Germani, Manes C., Pasquale Palumbo: Filtering for bimodal systems: the case of unknown switching statistics, IEEE Transaction on Circuits and Systems - I: Regular Papers 53(6), 1266-1277, 2006
  • Alfredo Germani, Manes C., Pasquale Palumbo, Pepe P.: A robust approximation scheme for the LQG control of an undamped flexible beam with a tip mass, European Journal of Control 12(6), 635-651, 2006
  • Alfredo Germani, Manes C., Pasquale Palumbo, Marco Sciandrone: A higher order method for the solution of a nonlinear scalar equation, Journal of Optimization Theory and Applications 131, 347-364, 2006
  • Pasquale Palumbo, Ong-Clausen W.H., Simona Panunzi, De Gaetano A.: Linear periodic models of subcutaneous insulin absorption: mathematical analysis, HERMIS Journal 7, 60-79, 2006
  • Alfredo Germani, Manes C., Pasquale Palumbo: Polynomial Extended Kalman Filter, IEEE Transactions on Automatic Control 50 (12), 2059- 2064, 2005
  • Alfredo Germani, Manes C., Pasquale Palumbo: Polynomial filtering for stochastic nonGaussian descriptor systems, Transactions on Circuits and Systems I-Fundamental Theory and Applications 51, 1561-1576, 2004
  • Alfredo Germani, Manes C., Pasquale Palumbo: Optimal Linear filtering for Stochastic Differential Systems with Unknown Inputs, IEEE Transactions on Automatic Control 47, 1726-1730, 2002
  • Pasquale Palumbo: A realizable observer for a flexible system with delayed outputs, in the Proceedings of 2nd IFAC Workshop on Time Delay Systems, Ancona, Italy, 2000
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