Publications of A.V. Greco

This page shows all publications that appeared in the IASI annual research reports. Authors currently affiliated with the Institute are always listed with the full name.

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IASI Research Report n. 356  (Previous    Next)


Bertuzzi A., Gandolfi A., Salinari S., Mingrone G., Greco A.V.

Pharmacokinetics of dicarboxylic acids in man

ABSTRACT
In this paper we examine the pharmacokinetics of two dicarboxylic acids, azelaic acid and sebacic acid, considered as possible alternative energy substrates in total parenteral nutrition. The plasma concentration profile and the 24-h urinary execretion were determied in healthy volunteers after a bolus dose, and during and after continous infusion. Experimental data were analyzed, for either dicarboxylic acids, by a two-compartment nonlinear pharmacokinetic model. In particular, tubular secretion appeared to be present in urinary excretion of azelaic acid, whereas tubular reabsorption was found in the case of sebacic acid. Cellular uptake was represented by Michaelis-Menten kinetics. The population mean of the pharmacokinetic parameters was estimated for both diacids.The maximal rate of tissue uptake is higher for sebacic than for azelaic acid but, compared to glucose and free fatty acids, appears not fully adequate for parenteral nutrition purposes. Preliminary data in rat indicate that another dicarboxylic acid (dodecanedioic acid) might represent a suitable energy substrate.
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