Publications of L. Guariglia

This page shows all publications that appeared in the IASI annual research reports. Authors currently affiliated with the Institute are always listed with the full name.

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Show all publications of the year  ALL, with author Guariglia L., in the category IASI Research Reports (or show them all):


IASI Research Report n. 125  (Previous )


Salinari S., Alessandro Bertuzzi, Vitelli R., Mancinelli R., Guariglia L.

In vitro motility of non-pregnant rat uterine horns: II. Mathematical model.

ABSTRACT
The pattern of the activatory inputs that control the spontaneous in vitro contraction of the rat uterine horn was investigated. A mathematical model was used in this study. The model simulates the time course of intraluminal pressure, longitudinal force, and wall morphology when the activatory inputs to the two mascular layers of the wall are assigned. The model needs also that the mechanical properties of the smooth muscle tissue are given: to this aim, the force-length and the force-velocity relationship of the myometrial tissue in both the longitudinal and circumferential directions were measured. The application of the model to experimental tracings of pressure and force allowed to determine, by an identification procedure, the following parameters: amplitudes of activatory signal in the ovarian and the cervical region of both wall coats, frequency of the low-frequency electrical signal that modulates the mechanical activity, modulation factors for the two coats, phase difference between slow waves in the two coats. Model results give confidence to the hypothesis (see the accompanying paper) that the spontaneous contraction in rat uterus is due to activation of separate horn regions, more than to a propagatory excitation.
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