Publications of Antonio Fasano

This page shows all publications that appeared in the IASI annual research reports. Authors currently affiliated with the Institute are always listed with the full name.

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Show all publications of the year  ALL, with author Fasano A., in the category IASI Research Reports (or show them all):


IASI Research Report n. 536  (Previous    Next)  

Alessandro Bertuzzi, Fasano A., Gandolfi A., Marangi D.

Cell kinetics in tumour cords studied by a model with variable cell cycle length

ABSTRACT
A mathematical model is developed that describes the proliferative behaviour at the stationary state of the cell population within a tumour cord, i.e. in a cylindrical arrangement of tumour cell growing around a blood vessel and surrounded by necrosis. The model, that represents the tumour cord as a continuum, accounts for the migration of cell from the inner to the outer zone of the cord and describes the cell cycle by a sequence of maturity compartments plus a possible quiescent comartment. Cell-to-cell variability of cycle phase transit times and changes in the cell kinetic parameters within the cord, related to changes of the microenvironment, can be represented in the model. The theoretical predictions are compared against literature data of the time course of the labelling index (LI) and of the fraction of labelled mitoses (FLM) in an experimental tumour after pulse labelling with ?H-thymidine. It is shown that the presence of cell migration within the cord can lead to a marked underestimation of the actual changes along cord radius of the kinetics of cell cycle progression.
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