Publications of Concettina Guerra

This page shows all publications that appeared in the IASI annual research reports. Authors currently affiliated with the Institute are always listed with the full name.

You can browse through them using either the links of the following line or those associated with author names.

Show all publications of the year  ALL, with author Guerra C., in the category IASI Research Reports (or show them all):


IASI Research Report n. 08-04  (Previous    Next)  

Paola Bertolazzi, Guerra C., Giampaolo Liuzzi

A global optimization algorithm for protein structure alignment

ABSTRACT
In this paper we propose a new method for protein structure alignment based on global optimization techniques. There is evidence [23, 9] that proteins with similar shape typically perform similar functions. Given the three-dimensional structures of two proteins, we are interested in finding the isometric transformation (rotation plus translation) that best aligns the two structures. We draw our inspiration from the well-known Iterative Closest Point (ICP) method for three-dimensional (3D) shapes registration. Our algorithm globally minimizes a dissimilarity measure between the two structures. The reported computational experience and comparison show viability of the proposed approach.
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