Publications

This page shows all publications that appeared in the IASI annual research reports. Authors currently affiliated with the Institute are always listed with the full name.

You can browse through them using either the links of the following line or those associated with author names.

Show all publications of the year  1988, with author ALL, in the category IASI Research Reports (or show them all):


IASI Research Report n. 215  (Previous    Next)


Bertuzzi A., Bizzarri M., De Santis A., Gandolfi A.

Parameter estimation by Maximum Likelihood in a model of Tryptophan renal excretion.

ABSTRACT
In order to study the relationship between plasma and urinary levels of Tryptophan, whose values were found to be increased in bladder cancer patients, a mathematical model of the Tryptophan reabsorption-excretion process was devised. The model embodies the mass balance between glomerular filtration, carrier-mediated reabsorption and excretion of the Tryptophan. The model parameters were estimated by the Maximum Likelihood procedure, using a set of clinical data measured on 30 bladder cancer patients and 7 healthy controls. Our study demostrates that Tryptophan excretion, in both groups subjects, is due to an overflow phenomenon without a clearcut threshold.
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