Publications of E. Arcieri-Mastromattei

This page shows all publications that appeared in the IASI annual research reports. Authors currently affiliated with the Institute are always listed with the full name.

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Show all publications of the year  1989, with author Arcieri-Mastromattei E., in the category IASI Research Reports (or show them all):


IASI Research Report n. 283  


Alessandro Bertuzzi, Gandolfi A., Salinari S., Mingrone G., Arcieri-Mastromattei E., Finotti E., Greco A.V.

Pharmacokinetic analysis of azelaic acid.

ABSTRACT
Azelaic acid (AZ) was the first dicarboxylic acid proposed as an alternative energy substrate in total parenteral nutrition. In this paper, pharmacokinetics of AZ was studied in two groups of healthy volunteers, who received i.v. a constant infusion (10 g AZ over 90 min) or a bolus (1 g). The 24-hrs urinary excretion and the plasma concentration in blood samples taken at regular intervals were assayed by gas-liquid chromatography. Experimental data were analyzed by a two-compartment nonlinear model that describes both tubular secretion and cellular uptake by Michaelis-Menten terms. It was found a high value of urinary excretion (mean 76.9% of infused dose), and a mean clearance of 140.4 ml/min suggesting the presence of tubular secretion. Estimation of the population mean of the model pharmacokinetic parameters gave a maximal cellular uptake of 0.657 g/h. The model predicts that 90% of the maximal uptake should be reached in the plateau phase of a constant infusion of 2.2 g/h. The present results indicate that AZ is scarcely utilizable as an energy substrate.
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