Publications of Alessandro Bertuzzi

This page shows all publications that appeared in the IASI annual research reports. Authors currently affiliated with the Institute are always listed with the full name.

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Show all publications of the year  1994, with author Bertuzzi A., in the category IASI Research Reports (or show them all):


IASI Research Report n. 395  (Previous    Next)


Bertuzzi A., Mingrone G., Gandolfi A., Greco A.V., Salinari S.

Pharmacokinetic analysis of dodecanedioic acid in man from bolus data

ABSTRACT
The pharmacokinetics of dodecanedioic acid (C12) was investigated in 7 overnight-fasting healthy male volunteers, who received i.v. a bolus (1 g) of C12. Blood samples were collected after bolus administration at intervals of 15 min, and C12 serum concentration was determined by high performance liquid chromatography. Twenty-four hours C12 excretion with urine was determined and found to be, on the average, 1.62% of administered dose. Binding of C12 in human serum was determined in separate equilibrium dialysis experiments by using an isotopic compound (disodic salt of (1,12)^14 C-dodecanedioic acid). The average number of binding sites per albumin molecule was 3.1 ? 0.2 (estimate?SE) with an affinity constant of 6.4+1.8 mM^-1. A two-compartment model was used for describing C12 kinetics. The apparent distribution volume of central compartment was 5.56 ? 3.13 L and that of peripheral compartment was 87.4 ? 30.4 L. The rate constant of exchange between compartment was 4.60 ? 3.50 L/min, that of urinary excretion 25.6 ? 15.5 mL/min, and that of tissue uptake 2.17 ? 0.86 L/min. These results are promising for C12 utilization in parenteral nutrition, since C12 elimination with urines is low whereas tissue uptake appears to be rather efficient.
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