This page shows all publications that appeared in the IASI annual research reports. Authors currently affiliated with the Institute are always listed with the full name.

You can browse through them using either the links of the following line or those associated with author names.

Show all publications of the year  1996, with author Ubezio P., in the category IASI Research Reports (or show them all):

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IASI Research Report n. 442   


Bertuzzi A., Gandolfi A., Carmela Sinisgalli, Starace G., Ubezio P.

Cell loss and potential doubling times

ABSTRACT

The in vivo infusion of Bromodeoxyuridine (BrdUrd), followed by delayed biopsy and bivariate DNA-BrdUrd flow cytometry, allows the Steel's potential doubling time of human tumors to be estimated. Two definitions of potential doubling time may be used: the potential doubling time can be defined as the doubling time that the population would exhibit if cell loss were removed (denoted here as ....) or, according to Stell, on the basis of the rate constant of cell production (T_pot). Although these two definitions are equivalent in the case of uniform random cell loss, we show, in the framework of the Steel's theory of growing cell populations, that T_pot and.... becomes distinct kinetic quantities when cell loss is not uniform, i.e. when it differently affects the quiescent and the proliferative compartment. We discuss the validity of the two formulas currently used for the calculation of T_pot, one based on LI and the other on the v-function, in conditions of non-uniform cell loss. Moreover, we propose two formulas for the estimation of the cycle time T_c, which require, in addition to T_s and LI, that a measure of the growth fraction be available.