Publications of M. Manco

This page shows all publications that appeared in the IASI annual research reports. Authors currently affiliated with the Institute are always listed with the full name.

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Show all publications of the year  1999, with author Manco M., in the category IASI Research Reports (or show them all):


IASI Research Report n. 511    

Mingrone G., Alessandro Bertuzzi, Capristo E., Greco A.V., Manco M., Pietrobelli A., Salinari S., Heymsfield S.B.

Unreliable use of standard muscle hydration value in obesity

ABSTRACT
Intramuscle water content is assumed to be constant in humans independently of their anthropometric characteristics. To verify if this assumption is correct, intramuscle water, proteins, glycogen, and both total and intramyocytic triglycerides, were measured in 51 samples of rectus abdominis muscle obtained from 16 lean and 35 overweight and obese subjects (BMI cutoff 24.9 Kg/m?). Data (referred to wet tissue) were analyzed by means of a composition model at the cellular level of the skeletal muscle (SM). The average SM water content was 76.3?3.3% in normal-weight individuals and 65.7?5.8% in obese subjects (P < 0.0001). Total triglycerides were 5.5?2.3% in controls, and 19.0?7.0 in obese subjects (P < 0.0001). The intramyocytic triglyceride fraction was also increased in obese subjects. The composition model provides an explanation for the negative correlation between total triglycerides and intramuscle water, and some of model parameters were determined from the data. In conclusion, although the hydration of fat-free SM mass may be unchanged in obese subjects, the hydration of in toto muscle mass decreases as its lipid content increases.
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