Publications of Alessandro Bertuzzi

This page shows all publications that appeared in the IASI annual research reports. Authors currently affiliated with the Institute are always listed with the full name.

You can browse through them using either the links of the following line or those associated with author names.

Show all publications of the year  1999, with author Bertuzzi A., in the category IASI Research Reports (or show them all):


IASI Research Report n. 514  (Previous    Next)  

Alessandro Bertuzzi, Gandolfi A.

The problem of evaluating the in vivo cell kinetics in tumours

ABSTRACT
A survey of mathematical models used to estimate kinetic parameters of cell cycle or paramenters related to the proliferation of a cell population using data of flow cytometry is presented in this work. Attention is focused on the analysis of sequential DNA-BrdUrd distributions that can be obtained from experimental tumours and on the estimation of T_s and T_pot from a single biopsy. The difficulties caused by the occurrence of cell loss are discussed and some models proposed to represent the proliferative heterogeneity of tumours are briefly presented. The assessment of the growth fraction of a cell population by proliferative markers and the methods for detecting the dead cells are finally considered
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