Publications of Alessandro Bertuzzi

This page shows all publications that appeared in the IASI annual research reports. Authors currently affiliated with the Institute are always listed with the full name.

You can browse through them using either the links of the following line or those associated with author names.

Show all publications of the year  1999, with author Bertuzzi A., in the category IASI Research Reports (or show them all):


IASI Research Report n. 516  (Previous )  

Alessandro Bertuzzi, Gandolfi A.

A model for estimating cell kinetic parameters of experimental tumours studied by bromodeoxyuridine labelling and flow cytometry

ABSTRACT
A mathematical model that describes the time evolution of the DNA-BrdUrd distribution, as measured in experimental tumours after labelling with BrdUrd, is proposed in this paper. Cell-to-cell heterogeneity within the tumour of the rate of progression across cell cycle phases is taken into account, and a strict correlation between the durations of S and G2M phases is assumed. The model relates observable quantities to the parameters that characterize the cell population kinetics (such as the potential doubling time, T_pot), and appears thus to be suitable for parameter estimation. Simulations that illustrate the dependence of model response on the kinetic parameters are presented.
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