Publications

This page shows all publications that appeared in the IASI annual research reports. Authors currently affiliated with the Institute are always listed with the full name.

You can browse through them using either the links of the following line or those associated with author names.

Show all publications of the year  2003, with author ALL, in the category IASI Research Reports (or show them all):


IASI Research Report n. 593  (Previous    Next)  

Bertuzzi A., Fasano A., Filidoro L., Gandolfi A., Carmela Sinisgalli

Dynamics of tumour cords following changes in oxygen availability: a model including a delayed exit from quiescence

ABSTRACT
In this paper we investigate the formation of tumour cords (cylindrical arrangements of tumour cells around blood vessels) within a tumour tissue. The shrinkage and the expansion of the cord following a stepwise decrease or, respectively, increase of oxygen tension in the blood vessel are also described. The model represents the tumour cell population as a continuum and includes two novel aspects with respect to our previous works: cell death does not occur instantaneously, but is preceded by a reversible pre-necrotic state; the recruitment of cells from quiescence into proliferation may require a recovery period. Model predictions are compared with experimental data reported by Hirst et al. (1991). Key words: Tumour cords, oxygen di ffusion, continuum modelling, free boundary problems.
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