This page shows all publications that appeared in the IASI annual research reports. Authors currently affiliated with the Institute are always listed with the full name.

You can browse through them using either the links of the following line or those associated with author names.

Show all publications of the year  2012, with author Germani A., in the category IASI Research Reports (or show them all):

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IASI Research Report n. 12-13  (Previous )  

Cacace F., Alfredo Germani, Pasquale Palumbo

A study on observer-based algorithms to infer information from gene expression data

ABSTRACT

In this paper a mathematical tool is presented, to estimate unknown variables of transcription networks, according to a set of measurements of the transcriptional activity of promot- ers. The approach is based on the use of the mathematical model of the network under investigation and on the state-reconstruction technique known as `state-observer', borrowed from the control the- ory. To this aim, besides the general case, the network motif of the Multi-Output Feed-Forward Loop (MO-FFL) will be investigated in details. Simulations show the eectiveness of the proposed approach in a wide range of possible critical frameworks, such as only one target gene measurements, non-smooth input perturbations, noisy measurements and model parameter uncertainties.