FISIOMAT – CNR-IASI

MITUS

2 Maggio 2024
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Il progetto MITUS presentato dalla capofila ADALTIS srl in aggregazione con CNR intende sviluppare una strategia focalizzata sulla ricerca e lo sviluppo di nuovi approcci diagnostici, terapeutici e preventivi attraverso lo sviluppo e attivazione di tecnologie innovative relative alle scienze della vita basate sulla Rolling Circle Amplification (RCA) per una soluzione diagnostica rapida, accurata e […]

PRIN2022-PRR-COL

22 Aprile 2024
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Major depressive disorder (MDD) is a severe illness that affects approximately 16% of people worldwide. Even though its etiology and pathogenesis are still unknown, evidence suggests that changes in signaling pathways, neuroplasticity, neuroinflammation, and neurometabolics are at the basis of this pathology. We will address the function of HDAC4 in MDD, since it is implicated […]

BIOMAT2-CL

2 Febbraio 2024
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Based on the interaction of the nucleoporin153 with HNRNPA2B1, a protein implicated in the recognition, binding and loading of miRNA in exosomes, we will investigate whether decreased levels of Nup153 in neural stem cells isolated from a mouse model of AD, lead to altered level of HNRNPA2B1 and processing and loading of miRNA in exosomes.

PRIN2022-COL

2 Febbraio 2024
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This project aims at investigating the double-faced role of HDAC4 in AD pathogenesis studying the loss of the positive HDAC4-dependent regulation of synaptic proteins in the cytoplasm along with the negative impact of HDAC4 nuclear localization on epigenetic regulation and gene expression. By molecular, electrophysiological, and behavioral approaches we will test the beneficial effects of […]

LIVERALIVE

2 Febbraio 2024
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Il progetto mira a sviluppare e testare un nuovo sistema diagnostico non invasivo più efficace per le malattie degenerative del fegato e a creare un innovativo protocollo per monitoraggio, diagnosi e prevenzione. Il sistema utilizza intelligenza artificiale e modelli matematici, integrando innovazioni tecnologiche in un nuovo protocollo di monitoraggio e diagnosi preventiva, comprendente anche un […]

SEARESCUE

16 Maggio 2023
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The S&R project aims at designing, implementing and testing, through a series of large scale pilot scenarios, a highly interoperable, modular open architecture platform for first responders involved in major crisis. The framework gives an effective and unified vision of the dynamic changes going on during event’s lifetime as well as the capabilities and resources […]

MOCARPO

16 Maggio 2023
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The main topics of the MoCarPo project are the modeling of the physiology of the cardiocirculatory and respiratory systems. By modeling the mechanics of these two systems it is possible to describe their fundamental aspects and provide medical staff with a tool for conducting in silico simulations as well as to support them in clinical […]

IMMUNAGE

16 Maggio 2023
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The rationale of this project is based on the hypothesis that epigenetic modifications may occur following the Sars-Cov2 vaccination, that are capable to affect the development of the immune response. The original experimental design involved the epigenomic analysis of 200-250 post-covid 19 and non-covid 19 subjects who underwent anti-Sars-Cov2 vaccination with Pfizer mRNA vaccine. And […]

RFBIO

16 Maggio 2023
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IASI is responsible for the bioinformatic analysis of gene expression data resulting from RNA sequencing of samples under different conditions, cells exposed and cells not exposed to RF pulses. The main steps of the analysis include: quality control, read alignment with a reference genome, and approaches to detect differential gene expression.

ATTENTIV

16 Maggio 2023
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The project foresees the development and validation of a decision support system for people affected by insulin-treated diabetes mellitus. The system will be able to leverage the readout of commercial continuous glucose monitoring sensors to make predictions about future blood glucose levels, in order to prevent adverse glycemic events. Aim of the project will be […]